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KMID : 0383820110710060417
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Tuberculosis and Respiratory Diseases
2011 Volume.71 No. 6 p.417 ~ p.424
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Association of p53 Expression with Metabolic Features of Stage I Non-Small Cell Lung Cancer
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Kang Shin-Myung
Koh Won-Jung
Suh Gee-Young
Chung Man-Pyo
Han Joung-Ho
Kim Ho-Joong
Kwon O-Jung
Um Sang-Won
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Abstract
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Background : Recent evidences have revealed metabolic functions of p53 in cancer cells; adaptation or survival to metabolic stress and metabolic shift toward oxidative phosphorylation. However, further studies in clinical setting are needed. We investigated whether p53 protein expression, as a surrogate marker for loss of p53 function, is associated with metabolic features of stage I non-small cell lung cancer (NSCLC), focusing on tumor necrosis and maximal standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography.
Materials and Methods : Clinical information was obtained from retrospective review of medical records. p53 expression was assessed by immunohistochemical staining.
Results : p53 protein expression was detected in 112 (46%) of 241 NSCLC cases included in this study. p53 expression was independently associated with the presence of necrosis (odds ratio [OR], 2.316; 95% confidence interval [CI], 1.215∼4.416; p=0.011). Non-adenocarcinoma histology (OR, 8.049; 95% CI, 4.072∼15.911; p＜0.001) and poorly differentiation (OR, 6.474; 95% CI, 2.998∼13.979; p＜0.001) were also independently associated with the presence of necrosis. However, p53 expression was not a significant factor for SUVmax.
Conclusion : p53 protein expression is independently associated with the presence of necrosis, but not SUVmax.
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KEYWORD
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Tumor Suppressor Protein p53, Necrosis, Positron-Emission Tomography, Carcinoma, Non-Small-Cell Lung
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